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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Formulation and evaluation solid dispersion based fast dispersible tablets of domperidone

Author: SHASHANK CHATURVEDI, MOHAMMAD ALIM
Abstract: Objective: Fast dissolving tablets of Domperidone (DOM) were prepared post solid dispersion inclusion complex formation for faster dissolution and action. Method: Domperidone-Solid Dispersion (DOM-SD) with hydrophilic carrier 2-hydroxypropy-ß-cyclodextrin (2HßCD) was prepared using solvent evaporation method in different ratio (1:2, 1:4, 1:6, 1:8 and 1:10). Moreover, DOM-SD was compressed into Domperidone fast dissolving tablets (DOM-FDT) by direct compression process employing either of the superdisintegrant (Kyron-T314/Sodium Starch Glycolate/Plantago ovata husk). The prepared solid dispersions were evaluated for drug-carrier compatibility by Fourier-transform infrared (FT-IR) spectrophotometric characterization. Furthermore, prepared DOM-FDTs were analyzed for pre-compression (percent drug content, yield, in-vitro drug release, phase solubility analysis and micromeritics characterizations) and post-compression parameters (Hardness, percent friability, percent weight variation, drug content, wetting time, disintegration time, in-vitro drug release water absorption ratio, and release kinetic studies). Results: Percent yield and drug content of DOM-SD was 67.00% - 93.04% and 59.50% - 91.13% respectively, FT-IR studies exhibited that all the characteristic peaks for DOM were remain to be intact when used either with the carrier or superdisintegrant. Pre-compression parameters warranted formulation of DOM-FDT. Post-compression parameters like thickness, hardness, weight variation, friability, percent drug content, water absorption ratio, wetting time, disintegration time and in-vitro dissolution suggested effective improvement and prompt release of DOM under simulated conditions. The selected formulation SF1 exhibited good stability data under accelerated conditions. Conclusion: The prepared DOM-FDT offered better solubility and faster in-vitro dissolution rate. Hence, these formulations can be effectively used for prompt and better relief from nausea and vomiting. Outline: Fast dissolving tablets of Domperidone (DOM) were prepared post solid dispersion inclusion complex formation for faster dissolution and action of DOM. Domperidone-Solid Dispersion (DOM-SD) with hydrophilic carrier 2-hydroxypropy-ß-cyclodextrin (2HßCD) was prepared using solvent evaporation method in different ratio (1:2, 1:4, 1:6, 1:8 and 1:10). Moreover, DOM-SD was compressed into Domperidone fast dissolving tablets (DOM-FDT) by direct compression process employing either of the superdisintegrant (Kyron-T314/Sodium Starch Glycolate/Plantago ovata husk). The prepared solid dispersions were evaluated for drug-carrier compatibility by Fourier-transform infrared (FT-IR) spectrophotometric characterization. Furthermore, prepared DOM-FDTs were analyzed for pre-compression (percent drug content, yield, in-vitro drug release, phase solubility analysis and micromeritics characterizations) and post-compression parameters (Hardness, percent friability, percent weight variation, drug content, wetting time, disintegration time, in-vitro drug release water absorption ratio, and release kinetic studies). Percent yield and drug content of DOM-SD was 67.00% - 93.04% and 59.50% - 91.13% respectively, FT-IR studies exhibited that all the characteristic peaks for DOM were remain to be intact when used either with the carrier or superdisintegrant. Pre-compression parameters supported formulation of DOM-FDT. Post-compression parameters like thickness, hardness, weight variation, friability, percent drug content, water absorption ratio, wetting time, disintegration time and in-vitro dissolution suggested effective improvement and prompt release of DOM under simulated conditions. The selected formulation SF1 exhibited good stability data under accelerated conditions. The prepared DOM-FDT offered better solubility and faster in-vitro dissolution rate. Hence, these formulations can be effectively used for prompt and better relief from nausea and vomiting.
Keyword: Solid-Dispersion, Fast Dissolving Tablet, superdisintegrant.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.019
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