*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice

Author: SANJIT NAMASUDRA, PANKAJ PHUKAN, MEENAKSHI BAWARI
Abstract: The study aims to assess the neurotoxic impacts of the ethanolic bark extracts of Holarrhena pubescens (HP). In this study, acute toxicity, as well as behavioral and histoarchitectural alterations in HP treated mice were examined. In acute toxicity study, the mice were observed for mortality and general behavior up to 14 days after the single oral administration of the test extract at doses of 1000, 2000, 3000, 4000 or 5000 mg/kg body weight. For evaluating the toxicity of the test extract on the body weight, relative brain weight, neurobehavioral and brain histology of mice, the plant extract was given orally to the mice for 28 days at the doses of 250, 500 and 1000 mg/kg body weight. The behavioral test viz. elevated plus maze test, open field test, forced swim test, and Morris water maze test was carried out to check anxiety, locomotion, depression, and memory and spatial learning of mice respectively. The ethanolic bark extract was also screen for phytochemicals. The LD50 of the test extract to be 4265.79 mg/kg body weight. The qualitative phytochemical test of the extract revealed the occurrence of alkaloid, flavonoids, phenolic and terpenoids. The outcome of the behavioral study indicates the reduction in locomotor activity, spatial memory and learning impairment, enhancement in anxiety and depression in HP treated mice. The histological experiments of the current investigation revealed prominent alterations in the treated mice brain. From the findings of the current study, it could be concluded that the ethanolic bark extract of HP possesses neurotoxic activity.
Keyword: Holarrhena pubescens, Phytochemical, Toxicity, Neurobehavior, Mice.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.011
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free