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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice

Author: SANJIT NAMASUDRA, PANKAJ PHUKAN, MEENAKSHI BAWARI
Abstract: The study aims to assess the neurotoxic impacts of the ethanolic bark extracts of Holarrhena pubescens (HP). In this study, acute toxicity, as well as behavioral and histoarchitectural alterations in HP treated mice were examined. In acute toxicity study, the mice were observed for mortality and general behavior up to 14 days after the single oral administration of the test extract at doses of 1000, 2000, 3000, 4000 or 5000 mg/kg body weight. For evaluating the toxicity of the test extract on the body weight, relative brain weight, neurobehavioral and brain histology of mice, the plant extract was given orally to the mice for 28 days at the doses of 250, 500 and 1000 mg/kg body weight. The behavioral test viz. elevated plus maze test, open field test, forced swim test, and Morris water maze test was carried out to check anxiety, locomotion, depression, and memory and spatial learning of mice respectively. The ethanolic bark extract was also screen for phytochemicals. The LD50 of the test extract to be 4265.79 mg/kg body weight. The qualitative phytochemical test of the extract revealed the occurrence of alkaloid, flavonoids, phenolic and terpenoids. The outcome of the behavioral study indicates the reduction in locomotor activity, spatial memory and learning impairment, enhancement in anxiety and depression in HP treated mice. The histological experiments of the current investigation revealed prominent alterations in the treated mice brain. From the findings of the current study, it could be concluded that the ethanolic bark extract of HP possesses neurotoxic activity.
Keyword: Holarrhena pubescens, Phytochemical, Toxicity, Neurobehavior, Mice.
DOI: https://doi.org/10.31838/ijpr/2020.12.04.011
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