|
Design, Development and Evaluation of Oral Sustained Release In-Situ Floating Gel as A Carrier for Stomach Specific Delivery of Anti Ulcer Drug.
|
|
| Author:
|
VIJAYSINH SABLE, MAHESH K. GUPTA, NEETESH K. JAIN, GURDEEP SINGH
|
| Abstract:
|
Gastroretentive drug delivery is one of the targeted strategy for prolonging gastric residence time, in management of peptic ulcer along with optimizing site-specific drug release for local or systemic impact in the upper gastrointestinal tract (GIT). Many gastroretentive drug delivery methods have been designed and developed over the last few decades. In present research, we have developed oral sustained release in-situ floating gel as a carrier for stomach specific delivery of anti Nizatidine (NZD). NZD is an antagonist of histamine H2-receptor. It is used commonly in severe duodenal ulcers, stomach ulcers, ulcerative esophagitis, heartburn. Nevertheless, the recent failure of proton pump inhibitors to suppress nighttime gastric acid spike (related to high nocturnal histamine concentration) and side effects from other H2-receptor antagonists (gyanacomastia) open a new path to NZD delivery at specific times in relation to symptom onset. Around 10 batches (F1-F10) were formulated and were subjected to determination of f2 value, viscosity (cps), gel strength (dyne/cm2), pH, drug content and in-vivo pharmacokinetic study. In-vivo investigations demonstrated that there was a marked difference in the reduction of ulcer index and volume of gastric acid secretion from nizatidine in situ gelling formulation (for optimized batch F6) when compared with the plain nizatidine solution (P < 0.01) and control group (P < 0.001). So, an effective oral sustained release in-situ floating gel as a carrier for stomach specific delivery of anti Nizatidine were formulated and evaluated successfully.
|
| Keyword:
|
Nizatidine, Oral Sustained Release, In-Situ Floating Gel, Stomach Specific Delivery.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.03.132
|
| Download:
|
Request For Article
|
|
|