IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
Life review of elderly depression
Development and application of ATR-FTIR spectroscopy for mixture homogeneity in pharmaceutical application
The Increasing Damage in Tubular Cell of Infant Mice’s Kidneys from Carbofuran Exposure during its Mothers’ Lactation Period
Trend of transsexualism problem and its implications towards muslim community in Malaysia
Development and validation of RP-HPLC method for the estimation of pidotimod in tablet dosage form
Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice
Design, synthesis and evaluation of 2-aminobenzimidazole derivatives: strong candidate for PPAR gamma agonists.
Prediction of Heart Disease Using Feature Selection and Random Forest Ensemble Method
Strategies for Antiviral Drugs from Plants by Targeting the Hemagglutinin, Neuraminidase and other receptors of Influenza A virus
The impact of human resource and quality management in health care: A Review
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Effect of meloxicam and its metal [Zn(II), Cu(II), Co(II), Ni(II)] complexes on viability and/or proliferation of human non-small cell lung cancer cells

Author: LORA DYAKOVA, DANIELA-CRISTINA CULITA, TANYA ZHIVKOVA, MILENA GEORGIEVA, ROSSEN SPASOV, GEORGE MILOSHEV, RENI KALFIN, GABRIELA MARINESCU, LUMINITA PATRON, RADOSTINA ALEXANDROVA
Abstract: The purpose of the present investigations was to study the effect of selective non-steroidal anti-inflammatory agent meloxicam and its metal [Zn(II), Cu(II), Co(II), Ni(II)] complexes on viability and proliferation of cultured A549 human non-small cell lung cancer (NSCLC) cells. The investigations performed by thiazolyl blue tetrazolium bromide (MTT) test (the gold standard for cytotoxicity assay) revealed that applied at a concentration range of 5 – 500 µg/ml for 24h, 48h and 72h, the compounds examined express cytotoxic effect that is time- and concentration- dependent. Tested independently, meloxicam exhibits the lowest cytotoxicity. The effective concentrations of meloxicam and its metal complexes that reduce the amount of viable cells by 50% (CC50) as compared to the control (DMSO-control) were found to be lower in NSCLC A549 cells as compared to human non-tumor lung embryonic Lep-3 cells. Cu(II) complex of meloxicam was found to exhibit the highest cytotoxic activity that was further confirmed by double staining with acridine orange and propidium iodide, AnnexinV/FITC test and 3D colony-forming method.
Keyword: meloxicam, metal complexes, non-small cell lung cancer, cell cultures, cytotoxicity
DOI: https://doi.org/10.31838/ijpr/2020.12.03.216
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free