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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Thyroid Abnormalities Associated with Complete Blood Count Parameter

Author: JONGKY PRAJITNO, SOEBAGIJO ADI SOELISTIJO, HERMAWAN SUSANTO, AGUNG PRANOTO
Abstract: Background: Abnormalities of thyroid hormone level may interferes human metabolism. There is much evidence about thyroid abnormalities and complete blood count (CBC) parameters, but the result is mostly controversial. This study evaluated the value of several parameters of CBC on patients with hyperthyroidism and hypothyroidism. Methods: This was a cross-sectional study using medical records from endocrine private clinics in Surabaya. CBC data from medical records were obtained and analyzed using statistical test. Results: Most patients with abnormalities of thyroid hormone level were female, 19 (44.1%) of hyperthyroidism, and 13 (30.2%) of hypothyroidism, respectively. Most patients were at productive age. There was statistically significant comparison among three groups, which was found in hemoglobin (P = 0.001), white blood cell (P = 0.044), mean cell volume (P = 0.001), mean cell hemoglobin (P = 0.001), and mean cell hemoglobin concentration (P = 0.001). On correlation test, Hb, MCV, and MCHC were significantly correlated and had strong positive correlation (CC >0.400) with TSHs and strong negative correlation (CC <-0.400) with fT4. Conclusion: Hyperthyroidism cause decrease, and hypothyroidism cause increase in Hb, MCV, and MCHC level.
Keyword: hyperthyroidism, hypothyroidism, complete blood count
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