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Evaluation of Pharmacological Activities of Itchy Leaf Extracts (Laportea decumana (Roxb.) Wedd.)
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| Author:
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EVA SIMAREMARE, ELSYE GUNAWAN, YULIANA RUTH YABANSABRA
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| Abstract:
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Itchy leaves [Laportea decumana (Roxb.) Wedd.] have been used as traditional medicine by Papuans as painkillers, for treating stiffness or aches, headaches, stomach aches, sore muscles, joints, and bruises. This study was conducted to evaluate the analgesic, anti-inflammatory, antibacterial, and antidiabetic activities of ethanol extract, ethyl acetate, and n-hexane leaves of L. decumana. In this research analgesic tests were carried out by the tail flick method, anti-inflammatory test: paw edema method, the antibacterial testing: disk method, and the anticoagulant test: Lee and White methods and the blood smear method. The results of the study of analgesic activity showed that there were significant differences in the treatment of ethanol, ethyl acetate, and N-hexane extract (sig < 0.05) dose of 200 mg/Kg BW. The anti-inflammatory test showed activity with values of 41.12% (ethanol extract), 47.27% (ethyl acetate extract), and 54.09% (n-hexane extract). The antibacterial activity test provided different activities where the best activity was evident in ethanol extract to E. coli bacteria with inhibition zone size of 13.93 mm at a concentration of 1,000 ppm and ethyl acetate extract against S. aureus with an inhibition zone size of 13.03 mm at a concentration of 1,000 ppm. In the anticoagulant activity test, Lee-white's ethyl acetate extract had anticoagulant activity at a minimum concentration of 75 ppm and ethanol extract of itchy leaves at a minimum concentration of 30 ppm.
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| Keyword:
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Itchy leaves [Laportea decumana (Roxb.) Wedd.], Analgesic, Anti-inflammatory, Antibacterial, Anticoagulant
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.199
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| Download:
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