IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
Life review of elderly depression
Development and application of ATR-FTIR spectroscopy for mixture homogeneity in pharmaceutical application
The Increasing Damage in Tubular Cell of Infant Mice’s Kidneys from Carbofuran Exposure during its Mothers’ Lactation Period
Trend of transsexualism problem and its implications towards muslim community in Malaysia
Development and validation of RP-HPLC method for the estimation of pidotimod in tablet dosage form
Evaluation of neurotoxicity of the ethanolic bark extract of Holarrhena pubescens Wall. ex G.Don in mice
Design, synthesis and evaluation of 2-aminobenzimidazole derivatives: strong candidate for PPAR gamma agonists.
Prediction of Heart Disease Using Feature Selection and Random Forest Ensemble Method
Strategies for Antiviral Drugs from Plants by Targeting the Hemagglutinin, Neuraminidase and other receptors of Influenza A virus
The impact of human resource and quality management in health care: A Review
12345678910...
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Effect of Green Tea (Camellia sinensis) Ethanol Extract Administration on The Number of Spermatogenic Cells of Male Mice (Mus musculus) Exposed to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

Author: SALSABILLA ABANI, WIDJIATI WIDJIATI, ERMA SAFITRI, MASLICHAH MAFRUCHATI, DJOKO LEGOWO, LLILIK MASLACHAH
Abstract: One of the cause of infertility in male reproduction is contamination of hazard chemical. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known as most toxic chemical which can impair the reproductive system and cause low count of spermatogenic cells. The purpose of this study was to know the effect of green tea (Camellia sinensis) ethanol extract on the number of spermatogenic cells of male mice (Mus musculus) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. This research used 25 male mice which divided into 5 groups of treatment i.eC(-) received aquadest only, C(+). T(1), T(2), and T(3) injected with TCDD 0,14 µg per mice and continued with the treatment. C(+) treated with Epigallocatechin gallate (EGCG) 1,2 mg/kg BW, T(1), T(2) and T(3) given green tea ethanol extract with a dose of 1 mg/kg BW ; 2 mg/kg BW and 4 mg/kg BW respectively orally 0.1 ml for 53 days. After that the mice sacrificied and the testis were taken for making histopathology slides using HE staining. The results showed that there are significant difference (P <0.05) of spermatogenic cells among the treatment group where T(1) with a mean of 100.68 ± 1.91, T(2) with a mean of 136.32 ± 2.33 and T(3) group with an average of 166.84 ± 3.40. Between T(3) and C(-) with a mean of 169.72 ± 2.67 showed there are no significant difference. The conclusion is green tea ethanol extract could maintain the number of spermatogenic cells.
Keyword: Green tea, Spermatogenic cells, TCDD
DOI: https://doi.org/10.31838/ijpr/2020.12.03.153
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free