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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Fourier Transform Infrared and Fluorescence Spectroscopic Analysis of H bonding variation in Human Benign and Cancerous Breast Tissues.

Author: G. DEVI, T. THANGEESWARI, T.MAGESH
Abstract: The infrared spectra and fluorescence spectra of various grades of breast cancerous tissues of human breast were studied. Significant differences in composition of water and proteins were noticed between normal and malignant breast tissues. The comparative spectroscopic studies of the absorption band in infrared region for the healthy and malignant breast tissues is done based on the curve – fitting method using principle of least squares. The spectral parameters in the frequency region 3100 – 3600 cm-1 of the normal, hyperplasia, fibro adenoma and carcinoma tissues show notable differences in the contents of proteins, strongly hydrogen - bonded water and weakly hydrogen- bonded water. Fluorescence spectroscopic investigation is also done for the above said samples. This procedure can classify between the diseased and healthy tissues. The results of this technique reveals that these spectroscopic differences will help us to know the limits of cutting edges for various operational processes and also this technique can display the spectroscopic response of tissue to various pharmaceutical therapies
Keyword: Fourier Transform Infrared spectroscopy, Fluorescence spectroscopy, breast cancer, water molecule, curve fitting, cancerous tissues
DOI: https://doi.org/10.31838/ijpr/2020.12.03.186
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