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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Kinetic Spectrophotometric Determination of Emtricitabine and Tenofovir Disoproxil Fumarate in Bulk and Pharmaceutical Dosage Form

Author: RAVI SANKAR KUNDERU
Abstract: A simple, accurate, reliable and sensitive kinetic spectrophotometric method for quantitative analysis of Emtricitabine and Tenofovir Disoproxil Fumarate in bulk and pharmaceutical dosage form has been developed. The proposed method is based up on oxidation reaction of drugs using alkaline potassium permanganate in the presence of sodium hydroxide at 60oC, resulted in formation of green coloured product, absorbed maximally at 610nm. Initial rate and fixed time methods were adopted for construction of calibration curve over a concentration range of 4-36µg/ml. Molar absorptivity, Sandell’s sensitivity, Limit of Detection, Limit of Quantification were also calculated. The proposed method was applied successfully for the determination of Emtricitabine and Tenofovir in pure drug and commercial dosage form.
Keyword: Emtricitabine, Tenofovir Disoproxil fumarate, Kinetic Spectrophotometric, Potassium permanganate, Initial rate method, Fixed time method.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.172
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