|
Effect of Ocimum sanctum (Tulsi) leaf extract on recovery of biochemical profiles in alloxan induced diabetic rats.
|
|
| Author:
|
ARPANA KUMARI, B. S. JHA
|
| Abstract:
|
This study reflects the efficacy of the aqueous leaf extract of Ocimum sanctum (Tulsi) on the recovery of biochemical profiles in the alloxan induced Wistar strain diabetic albino rats. 30 adult laboratory bred rats (5 months age) of average weight (117.0±12.0g) were randomly divided into 5 groups (G1-G5), each having 6 rats. Rats of G2-G5 were made diabetic by administering single dose (70 mg/kg body weight) of alloxan monohydrate dissolved in 0.9% sodium chloride solution. Rats of G3-G5 were supplemented with 200mg, 300mg and 400mg/kg body weight/day respectively of aqueous leaf extracts of Tulsi for 28 days. G1 rats served as control for G2 rats which in turn was designated as control for rats of G3-G5. A highly significant (p<0.001) increase was registered in blood glucose (273.30±1.08mg/dl); total serum cholesterol (198.86±1.62 mg/dl); LDL-C (169.74±2.78mg/dl); HDL-C (56.37±2.34mg/dl) and triglycerides (203.20±2.39mg/dl) accompanied by significant (p<0.01) decrease in serum protein (2.76± 0.18 g/dl) when compared to their control values of 94.98±1.23mg/dl; 117.83±1.24mg/dl; 78.42±3.24mg/dl; 42.82±2.68mg/dl; 112.62±2.43mg/dl and 6.94±0.62 respectively. At all the doses of treatment with Tulsi leaf extract all the above biochemical profiles exhibited recovery but the same were highly significant (p<0.001) in the rats of G5. The recovery levels brought the values. In this group nearer to those of G1 rats.Our findings suggest Tulsi leaf as having anti-hyperglycemic properties.
|
| Keyword:
|
Ocimum sanctum, diabetes, albino rat, blood glucose, serum cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol and serum protein.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.03.171
|
| Download:
|
Request For Article
|
|
|