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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Anti-hyperglycemic and Anti-hyperlipidemic effect of Rourea minor in streptozotocin (STZ) induced diabetic albino rats.

Author: UPLOADED BY-ADMIN, ANU CHAUDHARY, ANIL BHANDARI, A.PANDURANGAN
Abstract: Rourea minor (Gaertn.) Aubl. (Connaraceae), a woody vine (liana), is used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focuses on the serum insulin augmentation and anti-hyperglycemic property of methanolic extract of Rourea minor roots on streptozotocin induced diabetic rats. Type 2. diabetes was induced by administering intraperitoneal injection of a Freshly prepared STZ solution (60 mg/Kg og body weight) in 0.1M cold citrate buffer to the overnight fasted rats. The diabetes induced animals were fed with plant extract at the increasing dosage of 100mg, 200mg and 400mg of body wt. The combined plant extracts administrated animals revealed a significant (P<0.05) increment of serum insulin levels and higher reduction in hyperglycemia when compared to the diabetic control rats (P<0.05).
Keyword: Rourea minor, streptozotocin (STZ), hyperglycemia, glucose tolerance test.
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