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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Phenolic Compounds of Conocarpus on DNA Concentration and Biofilm Formation of Pathogenic Bacteria

Author: NIBRAS ABDULLA, BASAAD ABDZAID AL-FATLAWI, AQEEL A. ALSADAWI
Abstract: The aim of this study was to detect the effect of active compounds in fruit, leave and stem of Conocarpus (which extracted by methanol alcohol) on growth of Staphylococcus aureus, Enterococcus, E.coli, Klebsiella pneumonia, Proteus merabilis and Pseudomonas aeruginosa. Also, this study aims to detect the effect of active compounds separation from the methanol extract (phenol, alkaloid, and terpene) on bacterial growth, and study the effect of phenol and terpene which gave antibacterial activity as anti-biofilm. This study showed the methanolic extract gave higher effect on Staphylococcus aureus and inhibition zone diameter was 19mm, while the least effect was on Klebsiella pneumonia and inhibition zone diameter was 9mm. Also, the recent study showed the phenolic compounds were more activity than terpene on bacterial growth, while the alkaloid compounds were absent in methanol extract for all part, the phenolic compounds in of leave were higher effect than phenolic compounds in fruit and stem on bacterial growth. The ability of bacteria to the formation of biofilm and biofilm inhibitors by phenolic and terpene was investigated by phenotypic method. The results of the antibiotic sensitivity test showed that the bacterial isolates were highly resistant to the antibiotic; therefore, it is considered multidrug-resistance (MDR). Also, this study showed present variation in effect the phenolic and terpene on bacterial DNA.
Keyword: Conocarpus, phenol and terpene compounds, antibacterial, antibiofilm, DNA concentration
DOI: https://doi.org/10.31838/ijpr/2020.12.03.137A
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