IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Formulation & Evaluation of Matrix Type Transdermal Patches Based on Composite Polymers

Author: UPLOADED BY-ADMIN, M. N. PATEL, P. D. BHARADIA, M. M. PATEL
Abstract: There are two major transdermal therapeutic systems existing. Those are monolithic & reservoir type transdermal therapeutics systems. The present work aimed to develop a matrix-dispersion- type transdermal drug delivery system of Propranolol HCl using composite polymer. Oral administration of Propranolol has the disadvantage of low bioavailability due to an extensive and highly variable hepatic first-pass metabolism. Matrix type TDDS of propranolol HCl was formulated using polymer blend of Hydroxypropyl Methyl Cellulose (Methocel K4M) and Ethyl Cellulose (Ethocel STD 20) with a plasticizer, dibutyl phthalate. Patches of all batches had desired transdermal physicochemical properties. In vitro diffusion studies were performed through rat abdominal skin using a modified Franz diffusion cell. All prepared formulation shows percent drug permeation in the range of 59.66 to 99.83. The various permeation parameters such as diffusion rate, flux and permeability coefficients were determined for all formulation. Result of flux indicated that drug release was inversely proportional to polymer concentration. Diffusion rate of all formulation shows that diffusion rate was decreased with decrease in HPMC concentration. Both the independent variable selected had significant effect on drug permeation through rat skin (p < 0.05).
Keyword: Propranolol HCl, Transdermal, HPMC, EC.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free