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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Immunological role of CD4 and CD154 in patients infected with S.typhi in Al-Najaf Governorate, Iraq.

Author: EMAN MOHAMMED, AHMED ABDULJABBAR JALOOB ALJANABY
Abstract: Background: Salmonella Typhi (S.typhi) is one of the most important gram negative bacteria cause salmonellosis in worldwide. Materials and method: A total number of 60 outpatients infected with acute IgM and chronic IgG S.typhi were included in this study, serum concentration of CD4 and CD154 were measurement by Enzyme-linked Immune Sorbent Assay (ELISA) for each patient. Results: There was significant increase (P= <0.0001***) in serum concentration of CD+4 between patients with chronic S.typhi (IgG) (15.389 ± 0.46736 ng/ml) and healthy individuals (12.453 ± 0.30593 ng/ml) and there was significant increase (P value=0.0273***) in serum concentration of CD+4 in patients with chronic S.typhi (IgG) (15.389 ± 0.46736 ng/ml) as compare with serum concentration of CD+4 in patients with acute S.typhi (IgM) (13.883 ± 0.47338 ng/ml). Also, There was significant increase (P= <0.0001***) in serum concentration of CD+154 between patients with chronic S.typhi (IgG) (40.042 ± 1.5676 ng/ml) and healthy individuals (29.662 ± 0.84867 ng/ml). On the other hand, there was significant increase (P= 0.0393*) in serum concentration of CD+154 in patients infected with chronic S.typhi (IgG) (40.042 ± 1.5676 ng/ml) as compare with serum concentration of CD+154 in patients with acute S.typhi (IgM) (33.937 ± 2.4333 ng/ml). Conclusion: T-helper cell have an important immunological role in patients infected with chronic S.typhi infection due to activated of protein CD145 on antigen presenting cell. Therefore, CD4 and CD145 have synergistic immunological effect against S.typhi infection.
Keyword: Salmonella typhi, IgM, IgG, CD4, CD145, Iraq.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.140
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