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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Clinical efficacy and outcome of Oral and Intravenous Labetalol on preeclampsia pregnant mother and distressed fetus

Author: KOMAL RANI, CHANCHALA KUMARI, JASPREET KAUR, SIMMANJIT KAUR, PARMINDER NAIN
Abstract: Background: Drugs used to treat preeclampsia in pregnancy can adversely affect the health and life of the mother and fetus. The present study was designed to identify the clinical efficacy and other heath related outcome of oral and intravenous labetalol for treating preeclampsia on maternal and fetal distress. Methodology: This was a prospective observational six month study and conducted in a tertiary care teaching hospital. This study was performed on 75 pregnant women in which 50 women were suffered with preeclampsia and 25 women were included as controlled group. Subjects were selected on the basis of inclusion and exclusion criteria. Result: Oral and IV formulation of labetalol reduced mean systolic blood pressure and mean diastolic blood pressure significantly (P<0.05) but there is no significant difference in their clinical effect. The safety profile of both the drugs was similar. The APGAR score between the two groups were not statistically significant (P=0.05) even not statistically significant with control (normal) group. There were no maternal and perinatal adverse outcomes in the study group when compared with normal (control) group. Conclusion: Result of this study showed that Labetalol is effective in controlling the abnormal blood pressure during pregnancy and well tolerated without side effects.
Keyword: Preeclampsia, Fetus distress, Labetalol.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.106
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0.12
2018CiteScore
 
8th percentile
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