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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development, Optimization and Evaluation of Liquisolid Compact Tablet of Aripiprazole by using Factorial Design

Author: BHUPENDRA PRAJAPATI, SHRUTI RAO, TULARAM BAROT
Abstract: Liquisolid compact technique was selected to improve the dissolution profile of Aripiprazole. Aripiprazole is used for bipolar disorder, which requires quick action. Formulation was prepared by using Cremophor RH 40 as a non-volatile solvent. Carrier material was selected Neusilin US2 and Coating material was selected was Aerosil 200. Optimization of formulation was performed by applying 32 full factorial design. Further, the optimized batch was evaluated. Response surface graph was studied to check the effect of independent variables on dependent variables. The selected independent variables are Drug concentration in liquid medication (X1) and carrier: coating ratio (R) (X2) and dependent variable are cumulative % drug release at 15 min (Y1) and angle of repose (Y2). The optimized liquid medication was converted into solid power form by using adsorbent material. Further it was converted to tablet form and then was evaluated for different parameters.
Keyword: Liquisolid compact tablet, factorial design, In vitro dissolution study
DOI: https://doi.org/10.31838/ijpr/2020.12.03.094
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