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Preparation and Evaluation of Simvastatin Nanosponges
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| Author:
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SADHANA NOOTHI, NARENDER MALOTHU, UMASANKAR KULANDAIVELU, GSN KOTESWARA RAO, RAJASEKHAR REDDY ALAVALA, VISHNU PULAVARTHY
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| Abstract:
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The objective of the current work is to increase the solubility and release profile of Simvastatin by formulating into its nanosponges. The nanosponges obtained by complexing with cyclodextrin by the addition of dichloromethane as a cross-linker using solvent evaporation method. The compatibility of formulation components of Simvastatin was studied by Fourier-transform Infra Red (FTIR) spectroscopy. Further, developed nanosponges were evaluated for their particle surface morphology and size, entrapment efficiency, in vitro release criteria and release kinetics. The shape and their morphology of particles were examined by the scanning electron microscopy (SEM) analysis that showed the particle size of 113 nm with spherical in shape with uniformity. Moreover, no drug crystals observed on the surface of particles. In this study, it was found that one of nanosponge formulation was showed improved entrapment efficiency (89.36%±0.55), drug release (99.25%±0.61 in 1 2 hrs) characteristics to that of existed drug delivery systems and the release kinetics also showed that the optimized formulation was best suitable to Higuchi model and exhibits zero order drug release with super case 2 transport mechanism.
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| Keyword:
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Nanosponges, Simvastatin, BCS class-II, Cyclodextrin, Release kinetics.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.047
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| Download:
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