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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Designing of Cellular Immunity Inducing Epitopes for Iraqi Infectious Bursal Virus Strains

Author: AAISHA MAHMOOD, ZAHRA M.AL-KHAFAJI, ZAID YASEEN IBRAHIM
Abstract: Infectious Bursal Disease Virus (IBDV) causes Gumboro disease, the virus is widely prevalent in Iraq especially vvIBDV strains which are refractory to vaccines. In this study epitope vaccine for cellular immunity were designed using vaccinomics approach. Many MCH I epitopes were obtained, only three were satisfy the requirements: 9- SQYQGGVTI-17, 45- LVLGATIYL-53, 77- NLMPFNIVI-85, tow MHC II epitopes were obtained: 145- VATGSVVTVAGVSNF-159, 206- EYTDFREYFMEVADL-220. MHC I epitopes were docked with available chicken molecules obtained from pdb database, most of them were docked with good binding affinity and RMSD value of zero using Autodock vina. F MHC II only fist epitope was docked with available B-L allele (6kvm), the second was unable to dock, might be due to their secondary structure which was mainly as a-helix.
Keyword: Chicken MHC, Vaccine Design, Cellular Immunity Epitopes, Vaccinomics, Docking
DOI: https://doi.org/10.31838/ijpr/2020.12.03.119
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