IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Formulation of flurbiprofen as microsponge drug delivery system

Author: ZAHRAA KADHIM, HASANAIN SHAKIR MAHMOOD, MARYAM ALAAYEDI, MOWAFAQ M. GHAREEB
Abstract: Flurbiprofen (FP) is a drug which belongs to NSAIDs and is classified as class II by Biopharmaceutical classification system (BCS) with low solubility and high permeability. The aim of present study was to formulate flurbiprofen (FP) as a microsponge technology. This enhances the release of drug from the system. FP is a drug belongs to NSAID groups that classified as class II by BCS with low solubility and high permeability. This technology is a patented delivery system in which the drug loaded in pores of cross-linked polymers. In this technique, FP was mixed with two phases. In phase I and phase II, the polyvinyl alcohol (PVA) and Eudragit E100 were used, respectively, with a different doses of FP. The microsponge yield, entrapment efficacy, FTIR, particle size, and dissolution test were all studied. Preparation of FP loaded microsponge using Eudagit E100 in ratio of (500 Drug: 100 Polymer) succeed to enhance the drug dissolution rate with accepted entrapment efficiency and percentage yield.
Keyword: Microsponges, flurbiprofen, solubility.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.141
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free