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Synthesis and Characterization of Rosin Ester Derivatives of Polyethylene Glycol 200
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| Author:
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PRAMOD BURAKALE, DINESH SAKARKAR, SURESH SUDKE, MANISH BHISE
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| Abstract:
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The objective of present research was to synthesize and characterize rosin derivatives obtained from natural rosin by esterification reaction with polyethylene glycol 200. In this study, the conditions employed for esterification, the catalyst was prepared and evaluated for its performance. The reaction conditions like catalyst concentration, reaction time, temperature and molar ratio of PEG 200: rosin were optimized. The newly synthesized rosin derivatives were characterized for the determination of molecular weight, polydispersity, physicochemical properties, glass transition temperature etc. The rosin derivatives were further characterized by Fourier Transform Infra Red Spectroscopy, 1H Nuclear Magnetic Resonance Spectroscopy and 13C Nuclear Magnetic Resonance Spectroscopy. It was found that the rosin esters of polyethylene glycol 200 were synthesized successfully using Ni (NO3)2.6H2O (Zeolite modified nickel) as a catalyst at 2% mass of rosin maintaining temperature at 220-240 °C for 3 h at various molar ratios of polyethylene glycol 200: rosin.
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| Keyword:
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Drug delivery, film coating, sustained release, rosin derivatives
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.135
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| Download:
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