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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Injectable microspheres of erlotinib hydrochloride for sustained drug release.

Author: TEJESWINI V., RAJENDRA C. DOIJAD, ADHIKRAO V. YADAV
Abstract: The aim of this research was to formulation and evaluation of Injectable microspheres of Erlotinib Hydrochloride. Erlotinib HCL Injectable microspheres were prepared by O/W emulsion solvent evaporation technique using polycaprolactone polymer. Erlotinib HCL microspheres were evaluated for particle size, in-vitro release, in-vivo study, FTIR, DSC, X-ray diffraction study. All formulations showed good encapsulation efficiency i.e. 51.2 % to 86.8%.Amount of polycaprolactone influenced the properties of encapsulation efficiency of different formulations. The optimised formulation containing drug and polycaprolactone polymer showed the best results with 86.8 % drug entrapment efficiency and 95.23% sustained drug release at the end of 48 hrs. Polyvinyl alcohol acts as good emulsifying agent.Polycaprolactone based injectable microspheres of Erlotinib Hcl can be effectively used for target specificity and sustained drug release for extended period of time in treatment of different types of organ specific cancers like non-small cell lung cancer, pancreatic cancer, neck cancer etc.
Keyword: emulsion solvent extraction, Injectable microsphere, Target specific delivery, Erlotinib, Polycaprolactone, polyvinyl alcohol.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.134
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0.12
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