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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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An in-vitro study on antibacterial activity of homoeopathic medicines-Silicea, Sulphur and Mercurius solubilis against Pseudomonas aeruginosa

Author: DEEPALI TAK, RAMA KAUSTUBH BHADEKAR, ARUN BHARGAV JADHAV, MANISHA PRASHANT GAJENDRAGADKAR
Abstract: Pseudomonas aeruginosa is the main cause of nosocomial infections with the highest morbidity and mortality rate. The organism is known to have resistance to many broad-spectrum antibiotics. Hence the study was carried out to evaluate an in-vitro antibacterial activity of homoeopathic medicines Silicea, Sulphur, and Mercurius solubilis at various potencies against Pseudomonas aeruginosa. The experiments based on 96-well microtitre plate assay revealed 1M, 6C, 12C as the best potencies of homoeopathic medicines Silicea, Sulphur and Mercurius solubilis respectively. They were used in further experiments. In double dose studies, same homoeopathic medicines and different homoeopathic medicines were added at 8 h interval. Best results (>90% inhibition) were observed with Silicea 1M. The results were supported by triple dose studies wherein additions were done at 4 h intervals. Maximum inhibitory activity was recorded (>90% inhibition) in the sets containing Silicea 1M. The results with homoeopathic medicines were prominent, noteworthy and at par with modern drug Meropenem.
Keyword: antagonistic, complementary medication, drug resistance, mineral, potency, repetition of doses.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.095
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0.12
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