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Dexmedetomidine premedication: Effect On pressor Response To Laryngoscopy and Intubation
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| Author:
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PADMINI VISHWANATH, RAMMOORTHI RAO, SUNIL BAIKADI VASUDEVARAO
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| Abstract:
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OBJECTIVE: Dexmedetomidine and Fentanyl are used to attenuate the sympathetic response to laryngoscopy
and intubation. Aim is to study and compare the attenuation of haemodynamic response during laryngoscopy
and intubation.
METHODS: 60 ASA Class 1 & 2 patients aged between 18 -80 years, posted for elective surgeries were
randomized into two groups. GROUP C- Premedication with 2 mcg/kg Fentanyl and GROUP D -
premedication with 1 mcg/kg Dexmedetomidine + 2mcg/kg Fentanyl . Both groups were preloaded with
10ml/kg crystalloid solution. The parameters measured were propofol dose requirement for induction, heart
rate(HR), SBP,DBP and MAP(mean arterial pressure).
RESULTS: Propofol requirements were 26.6% lesser in Group D (P<0.000 HS). There was a initial rise of HR
during intubation in both the groups. Heart rate was significantly low at baseline( P;0.008) , induction (P;0.006)
and at intubation(P;0.001) in Group D. Cardiovascular parameters like MAP (P;0.007) SBP(P;0.005) and
DBP(P;0.007) were significantly lower in Group D compared to Group C only at baseline. There were no
differences at any other point during the study.
CONCLUSION: Dexmedetomidine decreases the requirements of propofol for induction and also attenuates
the haemodynamic response to intubation.
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| Keyword:
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dexmedetomidine, intubation response, propofol, fentanyl.
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| EOI:
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| DOI:
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