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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Analgesic and Antipyretic Effects of Ceiba pentandra L. Seed Extracts.

Author: UPLOADED BY-ADMIN, ALAGAWADI KALLANGOUDA R, SHAH AMOL S.
Abstract: Ceiba pentandra (L). Gaertn. (Bombacaceae) commonly known as silk cotton tree. The plant has been used as antibacterial, anti-inflammatory, antipyretic, in rheumatism, diabetes and in headache in Indian system of traditional medicine. Present study was carried out to evaluate the analgesic and antipyretic effects of petroleum ether and ethanolic extract of the seeds of Ceiba pentandra. Ceiba pentandra seeds were successively extracted by soxhlet extraction using petroleum ether (40-600C) and ethanol. Analgesic activity was assessed by heat induced pains (tail immersion model) and antipyretic activity using brewer’s yeast-induced pyrexia model. Oral administration of petroleum ether (40-600C) and ethanol extract at doses of 200 mg/kg and 400 mg/kg significantly reduced brewers yeast-induced pyrexia and also in tail immersion method extracts showed significant analgesic activity. These results clearly showed analgesic and antipyretic effects of seed extracts. Further studies are needed to clarify the mechanism of action and the phytoconstituents responsible for these pharmacological effects.
Keyword: Ceiba pentandra, analgesic, tail immersion, antipyretic, brewer’s yeast.
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