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Cardioprotective Effect of Garcinia combogia on Doxorubicin Induced Cardio toxicity in Rat
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| Author:
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UPLOADED BY-ADMIN, N.SUBHASHINI, G.NAGARAJAN, S.KAVIMANI
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| Abstract:
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The cardio toxicity of Doxorubicin has limited its use as an anticancer drug. The aim of present study was to investigate the
cardio protective effect of fruit rinds of Garcinia combogia water extract (GCWE) against the cardio toxicity of Doxorubicin
in rats. Male wistar rats (250-275 g) were randomly divided into four groups. Group I served as control and Group II as
disease control treated with doxorubicin 10 mg/kg for two days, i,e. day 17 and 18 groups III and IV were treated with
doxorubicin 10 mg/kg/i.p. on day 17 and 18and GCWE at the doses of 250 and 500 mg/kg/orally for 18 days from day 1,
After anesthetizing the animals on the 18th day, blood was investigated for creatine kinase-MBs enzyme (CK-MB), lactate
dehydrogenase and aspartate aminotransferase while determination of superoxide dismutase, reduced glutathione (GSH),
lipid per oxidation (LPO) and histopathology were carried out for heart. Significant decrease in serum CK-MB and AST of
group III (p<0.05) and group IV of animals was observed as compared to group II. In group IV significant increase in the
level of GSH and decrease in MDA content was observed as compared to group II, whereas SOD was non-significant.
Histopathological study of GCWE 500 mg/kg treated group showed protection against myocardial toxicity induced by
doxorubicin. It is concluded that Garcinia combogia water extract possessed good cardio protective effect at dose of 500 mg/
kg against doxorubicin induced cardio toxicity in rats than 250 mg dose.
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| Keyword:
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Garcinia combogia, myocardial toxicity, Antioxidant, tissue parameters histopathology
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| DOI:
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