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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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High Performance Thin Layer Chromatographic Estimation of Cefuroxime Axitel in Bulk and Pharmaceutical Formulation

Author: UPLOADED BY-ADMIN, MEENAXI M. MASTE, YUVARAJ D. MANDAVKAR, BHAT A.R
Abstract: A simple, fast, precise and accurate high performance thin layer chromatographic method has been developed for the estimation of Cefuroxime axitel in dosage forms. The chromatographic separation was developed using a pre-coated silica gel 60 GF254. TLC plate as stationary phase and a chromatogram was developed using chloroform: methanol: toluene (7:4:3 v/v/v) as mobile phase. Densitometric evaluation was performed at 289 nm. Cefuroxime axitel was resolved satisfactorily at Rf values 0.72 ± 0.001. The developed method was validated for accuracy, linearity, precision, limit of detection and limit of quantification and robustness as per the ICH guidelines. The calibration curve of HPTLC data was found to be linear between 300 to 800 ng/spot for Cefuroxime axetil. The limit of detection and the limit of quantification for the Cefuroxime axetil were found to be 9.85 ng/spot and 100.95 ng/spot. The proposed method can be successfully used to determine the drug content of marketed formulation.
Keyword: Cefuroxime Axetil (CA), Tablet form, HPTLC.
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