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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Impact of Methanolic Extract of Bauhinia racemosa Stem Bark on Brain Neurotransmitters and Antioxidant Levels in Swiss Albino Mice.

Author: UPLOADED BY-ADMIN, MRUNAL.S.DAVEY, CLEMENT ATLEE.W, R.PRAKASH, MOHAMED FAROOK
Abstract: The present study was performed to investigate the changes in the brain neurotransmitter and antioxidant levels in Methanolic extract of Bauhinia racemosa treated mice by estimating the levels of monoamines such as Serotonin, Dopamine and Nor-Adrenaline and enzymatic antioxidants including Superoxide dismutase, Catalase, Reduced glutathione, Glutathione peroxidase and Lipid peroxidation. Furthermore, the effects of Bauhinia racemosa extract were compared to a known active anxiolytic drug (Diazepam 2.5mg/kg, p.o). The extract was administered orally in two different doses of 150mg/kg and 300mg/kg for 7 days. Both the doses of B.racemosa extract treated mice shown significant (p<0.01) increase in the serotonin and nor adrenaline level as well as significant increment (p<0.001) in enzymatic antioxidant levels and decreased dopamine level in brain homogenate when compare to control group. This effect was comparable to that of the benzodiazepine diazepam (2.5mg/kg p.o.). Thus the results indicate that methanolic extract Bauhinia racemosa is an effective anxiolytic agent and act through serotonergic pathway.
Keyword: Brain neurotransmitter, Monoamines, Bauhinia racemosa, Antioxidants, Anxiolytic
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