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Hydrodynamically Balanced System: An Approach To Increase Gastric Residence Time
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UPLOADED BY-ADMIN, TARIQUE KHAN, SAYYED NAZIM, SIRAJ SHAIKH, AFSAR SHAIKH, MOHD HASIB AHMED.
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| Abstract:
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Now a day ’s controlled dr ug delivery system have been extensively used to improve drug therapy. But the improvement processes can face with several problems such as the inability to restrain and localize the system within the desired region of the gastroin testinal tract and the highly changeable nature of the gastric emptying process. This varia bility may lead to unpredictable bioavailability and difference in times to achieve peak plasma concentration. On the other hand, preparation of the drug in a controlled release hydrodynamically balanced system which can remain in the stomach for several hours would significantly prolong the gastric residence time of drugs an improve bioavailability, reduce drug waste, and enhance the
solubility of drugs those a re poorly solub le at high pH. Gastric retention would also facilitate local drug delivery to the
stomach Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatati on, mucoadhesion,
sedimentati on, expansion or by a modifi ed shaped syste m. The purpo se of writing this review on hydrodynamically
balanced systems was to compile the recent literature with special focus on the principal mechanism of floatation to achieve
gastric retention. The recent developments of hydrody namically balanced systems including the physiological and
formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems.
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Hydrodynamically balanced systems, gastric r etentation, sing le unit, multiple units, and in vitro evaluation.
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