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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development, characterization of novel microsponge loaded gel to treat various fungal infections

Author: PRAJAKTA K.KHULE, VRUNAL V.MORE, MANOJ M.NITALIKAR, RITU M.GILHOTRA
Abstract: Development, characterization of novel microsponge loaded gel to treat various fungal infections Aim: Transdermal delivery, a successful novel approach aimed at achieving systematically active level of drug. The work involves the drug Itraconazole which is antifungal. The micro sponge technology used to facilitate the controlled release of active drug into the skin in order to reduce the systematic exposure and minimize local cutaneous reactions of active drugs. The main objective of this work was to design and evaluate the gel formation of microsponge entrapped Itraconazole to increase the effectiveness of the treatment. Materials and Methods: The microsponges were prepared by quasi emulsion solvent diffusion method. The internal phase consisting eudragit RS-100 dissolved in dichloromethane and ethyl alcohol. Microsponges was characterized by parameters like scanning electron microscopy, drug content, particle size analysis, compatibility studies using differential scanning calorimetry. Microsponge-loaded gel was characterized by physical parameters of gel, measurement of PH, viscosity study, Drug content study, in-vitro release studies using first order kinetics, Higuchi Model, Peppas release Model. Results: The different kinetics models showed that the release data followed Higuchi matrix and the release mechanism from microsponges was diffusion. Conclusion: From the results, it can be concluded that MF3 formulation shows drug release in a controlled manner
Keyword: Antifungal gel, Itraconazole, microsponges
DOI: https://doi.org/10.31838/ijpr/2020.12.03.088
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