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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparison of Effects of Vaginal Progesterone and Intramuscular Progesterone on Prevention of Labor in Woman with a High Risk of Spontaneous Preterm Delivery

Author: RAZIEH VANDA, MOHAMMAD ZOLADL, SHAHINTAJ ARAMESH
Abstract: Background and objective: Premature deliveries that increase with rapid acceleration, is one of the main causes of neonatal morbidity and mortality. Accordingly, since the controversy about the first-line drug for the prevention of preterm labor, this study was aimed to compare the effect of vaginal progesterone and intramuscular progesterone to prevent labor in women with a high risk of spontaneous preterm delivery. Method and material: Among women with a singleton fetus with a high risk of preterm birth who refer to the Shahid Mofateh clinic affiliated to the Yasuj University of Medical Science, 166 eligible pregnant women were selected and allocated into following two groups the quadratic randomized block allocation: 1- treatment with daily vaginal progesterone until the presentation of delivery sign and symptoms; and 2- treatment with weekly intramuscular progesterone until starting the labor pain. The data of these women, such as age, para, gravid, lived, abort and death, history of preterm delivery, the situation of cerclage placement, and the timing of the onset of labor and termination of pregnancy were recorded, then these data were analyzed using SPSS 21 software, through descriptive and inferential statistics at a 95% confidence level. In this study, ethical considerations were respected. Results: At the beginning of the study, the women of the group of daily vaginal Progesterone and the group of weekly intramuscular Progesterone were the same in terms of quantitative and qualitative variables (p>0.05). The mean and standard deviation of the time of onset of labor and pregnancy duration were 33.9±3.6 weeks and 36.1± 3.2 weeks in the group of daily vaginal Progesterone, while these indices were 34.8±2.9 weeks and 36.5±2.7 weeks in the group of weekly intramuscular Progesterone respectively, which there were not significantly different between the two study groups (p>0.05). In this study, there were no significant differences between two study groups regarding success rate in the prevention of preterm labor (p>0.05). Also, the result indicated that in women of both two research groups, there were no significant differences in the success rate of the prevention of preterm delivery in terms of the status of cerclage placement (p>0.05). Conclusion: Both daily vaginal Progesterone and weekly intramuscular Progesterone had no additional benefit for preventing childbirth in women at high risk of spontaneous preterm labor. Also, the presence or absence of cerclage placement was not produced a significant difference in the length of pregnancy.
Keyword: Preterm delivery, Intramuscular progesterone, Vaginal progesterone, Cerclage placement
DOI: https://doi.org/10.31838/ijpr/2020.12.03.087
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