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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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No Significant Relationship of Ferritin Levels to the Levels of Platelet-derived Growth Factor (PDGF) in the Peripheral Blood of Transfusion-dependent ß-Thalassemia Major Patients with Growth Retardation

Abstract: Introduction: Platelets-derived-growth-factor (PDGF) is dimeric glycoprotein contain monomers covalently joined by disulfide bonds, which belongs to the growth factor family. It is a potent mitogen for a variety of cell types can be secreted by thrombocyte, macrophage, osteocyte, and fibroblast. PDGF can control cell growth and division including basic hematopoietic precursors, erythroid and platelets precursors. Ferritin is an extremely conserved iron-binding protein can safely sequester iron representing iron status; however the levels of nonbinding iron adjust cellular ferritin values. In thalassemics, plasma ferritin is a reliable monitoring biomarker for iron overload. The iron-overload in several organs may cause severe complications like endocrine, and growth abnormalities even with the extended chelator treatments. Stunted growth may ensue in thalassemic children and it is multifactorial. Aim of the study: an attempt to address the issue of the association of levels of ferritin to that of PDGF in the blood, and its relationship to the growth retardation in ß-thalassemia patients. Materials and Methods: This cross-sectional analysis comprised 163 patients with ß-thalassemia major and 49 sex-matched healthy control. Records recruited of the thalassemic patients registered at the Babylon thalassemia center. The thalassemic subjects categorized according to their growth status, into three groups: the first group included subjects with mild growth retardation (GR), the second group was subjects with short stature (stunted growth) & those with no GR were considered as a third group (normal thalassemics). The clinical examination involved anthropometric measurements; while the laboratory investigations included serum ferritin and serum PDGF. PDGF levels evaluated by enzyme-linked immunosorbent assay using PDGF ELISA kit following the manufacturer’s instructions. Statistics completed using SPSS software version 25. A P-value of less than 0.05 considered significant. Results: The mean age of the patients with mild growth retardation was 12.6, those with short stature was 14.1 and those with normal growth was 12. There was no significant difference among the groups as regards age and sex distribution. There was significant statistical variation regarding the length and weight of the included subjects. The levels of ferritin varied significantly among the four groups being higher in thalassemics with short stature and lower in the controls, which is not the case for the levels of PDGF in the blood. PDGF in the serum has poor strength of the relationship with serum measurements of ferritin in all four groups. Ferritin was correlated significantly with the degree of stunting and wasting in thalassemic patients. Serum PDGF was not correlated to the anthropometric measurements in thalassemics but the situation was different for the height & weight ZScores in normal thalassemics & controls. Conclusion: No significant relationship of ferritin levels to the levels of platelet-derived growth factor in the peripheral blood of transfusion-dependent ß-thalassemia major patients with growth retardation. Ferritin levels were correlated with stunting and wasting in thalassemic patients. However, PDGF was not correlated with growth status and weight in thalassemic patients.
Keyword: platelets derived growth factor, PDGF, ferritin, thalassemia, growth retardation, short stature.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.084
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