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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Comparative Study of the Tocolytic Effects of Magnesium Sulfate and Indomethacin on Pregnancy Duration and Neonatal Outcomes in Preterm Labor: A Clinical Trial

Author: HANIEH TOGHROLI, SARA ESMAELZADEH SAEIEH , RAFAT REZAPOUR-NASRABAD , MITRA RAHIMZADEH, MINA ATAEI , ALI FARAJI
Abstract: Introduction: Preterm labor is still one of the most serious complications of pregnancy. Many drugs have been used to control preterm labor, but their definitive effect is not known. Hence, this study was conducted to compare the tocolytic effects of magnesium sulfate and indomethacin on pregnancy duration and neonatal outcomes in preterm labor. Methodology: The present study was a randomized clinical trial study conducted at Kamali Hospital of Alborz Province. Research samples included 211 mothers with singleton pregnancy, healthy amniotic membrane, gestational age over 25 and less than 32 weeks, regular uterine activity as contraction in 20 minutes or cervical changes of 1 cm / h or effacement equal or more than 80%. Sampling was performed using convenience and randomized method through a random number table. Accordingly, both groups received the initial neuroprotection of magnesium sulfate at doses of 6 mg. Then, subjects of one group received 50 mg of indomethacin suppository at 8-hour intervals so that they could finally receive 4 doses. The subjects of another group received magnesium sulfate 2 g/ h as intravenous infusion for at least 12 hours after discontinuation of contraction. Then, two groups were compared in terms of difference of gestational age at hospitalization and discharge times, neonatal Apgar score, and rate of neonatal hospitalization in ICU though SPSS software. Results: The results of independent t-test showed that there was no significant differences between two groups in terms of gestational age at discharge and hospitalization times (p <0.8). Also, the rate of neonatal hospitalization in sulfate group was lower than that of the indomethacin group and this difference was statistically significant (p <0.03). The most common cause of hospitalization in ICU was respiratory distress that was higher in the indomethacin group. Conclusion: Magnesium sulfate reduced neonatal hospitalization in ICU compared to indomethacin. The use of tocolytic magnesium sulfate and indomethacin increased the duration of pregnancy, but no difference was seen between these tocolytics.
Keyword: Preterm labor, Magnesium sulfate, Indomethacin, Tocolytic
DOI: https://doi.org/10.31838/ijpr/2020.12.03.082
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