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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis, Design, Docking and biological activity of new benzo hydrazide derivatives.

Author: ZAHRAA KETAN, AHMED W. NASER, HANADY S. AL-SHMGANI
Abstract: Throughout this work, some new heterocyclic compounds have been synthesized from Esterification of benzoic acid derivative (1a) with absolute ethanol in presence of concentrated sulfuric acid to get ester derivative (2a).benzo hydrazide derivative (3a) was prepared from the reaction of compounds (2a) with 99% hydrazine hydrate. Schiff’s bases (4a-d) were synthesis via the condensation of compound (3a) with some aromatic aldehyde; such as p-hydroxybenzaldehyde, p-dimethylaminobenzaldehyde, p-nitrobenzaldehyde and p-methoxybenzaldehyde . 5-mercapto-4-amino-1,2,4-triazol compound (5a) was prepared via the cyclization of (3a) with carbondisulfide in presence of potassium hydroxide. Schiff’s bases (6a,b) were prepared by the condensation of (5a) with some aromatic aldehyde; p-hydroxybenzaldehyde and p-methoxybenzaldehyde. Reaction of (3a) with allyl bromide gave N-allyl benzo hydrazide derivative (7a) . Cyclization of (7a) with some azides such as (p-nitro benzyl azide , benzyl azide , p-aminoacetophenone azide and p-toluyl azide) gave the corresponding 1,4-disubstituted 1,2,3-triazole derivatives (8a-d) .All synthetic compounds were definited by their melting point, FT-IR spectra and 1H-NMR and 13C-NMR spectra, Antioxidant activities, Anti-microbial activity and Molecular Docking for some of them compounds.
Keyword: Schiff’s bases, benzo hydrazide, Antioxidant activities, Anti-microbial activity and Molecular Docking.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.070
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