IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Synthesis and identification of some new N-substituted quinazoline-4-one, thiazine-4-one and tetrazoline rings incorporating N-ethyl-2-(benzylthio)benzimidazole acetate and study their application as anti-oxidant agent

Author: HALAH R., SUAAD M. H. AL-MAJIDI, YASSER A. H. AL-ISSA
Abstract: A new series of 2-Mercaptobenzimidazole derivatives were synthesized. Quinazoline-4-one, thiazine-4-one and Tetrazoline derivatives. These compounds can be prepared by alkylation of 2-Mercaptobenzimidazole [2-MBI] with benzyl chloride in basic medium to produce 2- benzyl thiobenzimidazole [1], then the compound [1] was mixed with sodium hydride in dioxane at (0-5C0) to give the salt of compound [1]. Then the salt was reacted with ethyl chloro acetate to yield ethyl 2-(benzylthio) benzimidazole acetate compound [2] as a starting compound [2]. Thereafter, compound [2] was treated with hydrazine hydrate to afford N-acetohydrazide-2-(benzyl thio) benzimidazole [3] then reacted with a different substitution aromatic aldehyde in absolute ethanol to give Schiff's bases derivatives [4-10]. The reactions of compounds [4-10] were carried out through three pathways for cyclization: the first pathway involved a reaction with 2- amino benzoic acid to afford Quinazoline-4-one derivatives [11-17]. The second pathway consists of reaction with 2-marcaptobenzoic acid to produce thiazine-4-one derivatives [18-24]. The third pathway involved reaction with sodium azide to obtain tetrazoline derivatives [25-31]. The new prepared compounds were identified by [FTIR, 1H-NMR and 13C-NMR] and their physical properties were measured. Furthermore, we have evaluated of anti-oxidant activities in-vitro of the new synthesized compounds were tested with DPPH radical cation decolorization assays.
Keyword: 2-Mercaptobenzimidazole, Schiff's bases, Quinazoline-4-one, Thiazine-4-one, Tetrazoline, anti-oxidant, DPPH radical scavenging.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.069
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free