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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Efficacy of Ozonated Saline Solution against Protoscoleces of Cystic Echinococcosis in Liver Hydatid Surgery

Author: KASSIM FAWZI, ASAAD MOHAMMED KADHIM , MADHI HASHIM OTAIWI
Abstract: Echinococcus granulosus (Hydatid cyst) infection is one of the most common parasitic diseases that affect the liver. The cyst represent the larval stage of the parasite. The disease course is typically slow and the patients tend to remain asymptomatic for many years. The available and currently used treatment for E. granulosus infection include open surgery, percutaneous interventions, and pharmacotherapy. Ozonated saline solution is commonly used as a safe and efficient disinfectant for treatment of infections that occur during deep wounds and injuries. It is a potential adjuvant therapy to treat wounds and effective way of sterilization. The aim of the present study is to use ozonated saline solution in vitro for killing hydatid protoscoleces. Materials & Methods: Samples of hydatid fluid were collected from hydatid cysts obtained from patients operated on due to liver hydatid cysts after operations for liver cystic echinococcosis. They were treated separately with the normal saline and ozonated saline. Then, the samples were examined microscopically for viability of protoscoleses by using 0.1% eosin stain. Results: All protoscolices were dead after treatment with ozonated saline solution, i.e. 100% lethal effect, as they stained red after absorbing the eosin stain used in the viability test. Whereas non-azonated saline solution had no scolicidal effect. The ozonated saline solution showed a potential to kill the hydatid protoscolices in vitro which could be tried as a new method in vivo during operations of hydatid cystectomy without fear of toxic effects. Ozone is a safe non-toxic gas which becomes oxygen afterwards. Conclusion: As per the author’s best knowledge, this is probably the first research to prove the in vitro efficacy of of ozonated saline solution in the management of hydatid cysts.
Keyword: Ozonated saline, Protoscoleces, hydatid fluid, liver hydatid, surgery
DOI: https://doi.org/10.31838/ijpr/2020.12.03.066
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