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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effectiveness of oral colchicine in the management of lichen planus

Author: HUSSEIN AL-SULTANY, AHMED ABDULHUSSEIN KAWEN
Abstract: Aim and objectives: The goal of present work is to record the increase in the rate of lichen planus in Iraqi people and to study the effectivity and safety of colchicine as a therapeutic option among lichen planus patients. Materials and methods: This study in a design of a cross-sectional, 92 patients of lichen planus, were enrolled from those patients referred the outpatients clinic of section of dermatology and venereology in Merjan teaching hospital and Alhussein teaching hospital in Thi Qar , Iraq for a period extended from Jan. 2018 to Jan. 2019. Oral colchicine 1 g once daily was prescribed to every lichen planus patients in the study. Duration of therapy extended from one month to three months then follow up for another three months. Response to treatment was reported at every visit. Photographs were taken at both pre and post treatment visits. Results: Out of the entire 92 patients involved in the study, 4 patients withdrew from the study because of gastrointestinal side effects of colchicine, while 3 patients were missed to follow up thus were omitted from the study. Beyond the residual 85 patients 39 were males (46%) and 46 females (54%) (female to male ratio 1.18:1). Age of patients ranged from 19-56 years. The most common type of lichen planus was classical type followed by actinic lichen planus, oral lichen planus was the third in frequency, while lichen planopillaris was the fourth making hypertrophic variant of lichen planus as the least common clinical variant. Enhancement in lichen planus lesions was more noticeable and obvious in patients who were under colchicine therapy for prolonged interval (the full three months). Good improvement ( <70% reduction in the severity of lichen planus lesions) was noted clinically in 55 patients forming (64.7%) of all patients in the study. Moderate response (30-70% improvement) was detected in 22 patients forming (25.8%) out of total patients. Otherwise poor response to colchicine therapy (less than 30% improvement in lichen planus lesions) was seen in 8 patients only forming (11.7%) out of all patients in this study. Conclusion: colchicine seems to be effective drug, safe and good choice for those challenging cases of lichen planus.
Keyword: colchicine, lichen planus, treatment modalities, Iraqi patients.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.057
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