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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis of biogenic silver nanoparticles using Zanthoxylum rhetsa (Roxb.) DC seed coat extract as reducing agent and in-vitro assessment of anticancer effect on A549 lung cancer cell line

Author: SREENIVASA NAYAKA, BIDHAYAK CHAKRABORTY, PALLAVI SS, MEGHASHYAMA P BHAT, SHASHIRAJ KN, BHAGYALAXMI GHASTI
Abstract: The use of silver for different purposes was extending from the beginning of human civilization, but the fabrication of silver into silver nanoparticles (AgNPs) has been invented recently. At present, the biosynthesis of AgNPs is one of the most active areas in the field of nanoscience and research. In this study an eco-friendly, cost-effective and green synthesis method of AgNPs was described from Zanthoxylum rhetsa (Roxb.) DC seed coat extract. After synthesis, the existence of AgNPs was confirmed by UV-Vis. spectrophotometry, atomic force microscope (AFM), transmission electron microscope (TEM), scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffraction spectroscopy (XRD) and fourier transform infrared spectroscopy (FTIR) analysis. The antibacterial property was evaluated against four pathogenic bacteria, such as Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae and Enterococcus faecalis. In order to carry out a cytotoxicity assay, the A549 cell line was used for MTT assay. The UV spectral analysis revealed a maximum absorbance peak at 426 nm, confirmed the formation of AgNPs. The spherical and poly-dispersed nature of AgNPs was confirmed with AFM, TEM and SEM analysis and the size obtained in the range of 10 nm to 68 nm. FTIR study confirmed the presence of proteins on the surfaces of AgNPs. The evaluation through antimicrobial studies revealed AgNPs effectiveness against all the pathogenic bacteria; finally, MTT assay revealed that synthesized AgNPs have good anticancer activity against A549 Lung cancer cell line.
Keyword: Zanthoxylum rhetsa, FTIR, TEM, XRD, Anticancer, A549 cell line
DOI: https://doi.org/10.31838/ijpr/2020.12.03.024
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