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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of the biocompatibility of nitrofurantoin as an experimental intracanal medicament in endodontics therapy

Author: MEWAN A.ALRAHMAN, BESTOON MUHAMMED FARAJ, KAWA F. DIZAYE
Abstract: Background and Objective Intracanal medicaments are used as a cornerstone to minimize the chances of the bacterial colonization of root canal systems. Biocompatibility and stability are essential properties for intracanal medicaments. Introducing new intracanal medicaments in endodontics need to be tested in vivo before applying in human beings. Thus, this study aimed to compare the biocompatibility of two concentrations of a new intracanal medicament paste nitrofurantoin with a modified triple antibiotic paste (MTAP), in rats’ subcutaneous connective tissue. Materials and Methods: Twenty-four female Wistar rats were divided into four groups of 3, 7, 14, and 30 experimental days. Sterile polyethylene tubes were filled with 12.5mg/mL nitrofurantoin paste as tested group 1 (TG1), 25 mg/mL nitrofurantoin paste as tested group 2 (TG2) and 25 mg/mL modified triple antibiotic paste (MTAP) as a positive control group (PC) and implanted subcutaneously. Empty tubes were implanted as a negative control group (NC). After the experimental periods, animals were euthanized by anesthetic overdose. The implantation sites were excised, and the specimens were subjected to histochemical preparation. The classification of the inflammatory process intensity was according to established scores. Result: The intensity of inflammatory response was more in PC than TG1 and TG2 in all period intervals, and the difference was statistically significant (P<0.05) in days 3, 7, and 14 but non-significant in day 30 withTG1, while with TG2, the difference was statistically significant in days 3 and 7 (P<0.05) but non-significant in days 14 and 30 (P>0.05). The intensity of inflammatory response was more in TG2 than TG1 in all period intervals but the difference was statistically non-significant (P>0.05). The intensity of inflammatory response in TG1 and TG2 were more than NC in all time intervals and the difference was non-significant (P>0.05) except at day 3 and 7 in TG2, the difference was statistically significant (P<0.05) Meanwhile, PC demonstrated significant differences with NC in all four-period intervals (P<0.05). Conclusion: According to the results of the current study, the two used concentrations of nitrofurantoin paste (12.5mg/mL and 25mg/mL) were biocompatible with the rat subcutaneous connective tissue and were comparable with that of MTAP (25mg/mL).
Keyword: Biocompatibility, Intracanal medicament, Nitrofurantoin, Modified triple antibiotic paste.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.043
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