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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The effect of some plants extract on hormonal and testicular function in rats

Author: SALAH AL, RANA IBRAHIM MAHMOOD
Abstract: Infertility is one of the main health problem in developing countries, and among the complex issues in medicine. In recent years, medical plants has been widely used in the treatment of infertility. This study aims to investigate the role of mix extract of three plants( Eruca sativa , Apium graveolens L.,and Nigella Sativa) on follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone hormone levels, sperm count, viability, motility, and abnormalities as well as evaluate the effect on malondialdehyde (MDA), Glutithione peroxidase, VitE,C, and A. The aqueous leaves and seed extract of three plants were prepared and then chemical analysis were done, the results revealed that, alkaloids, glycosides, flavonoids, saponins and terpens were present in mix extract. The fertility effect was carried out by treating rats with a dose of 100mg\kg body weight of Lead acetate and 300 mg/Kg of extract. After 35days of treatment the results showed a significant (p= 0.05) increase in testosterone ,FSH ,LH levels, sperm count , viability, motility and a significant decrease in sperm mortality and abnormalities were recorded. Also the results investigated a significant (p= 0.05) decrease in MDA level and significant (p= 0.05) increase in Glutithione peroxidase ,Vit. E,C and A in groups treated with mix extracts and treated with lead acetate and mix extract compared to group treated with Lead acetate only and control.
Keyword: three plants extract, male fertility, lead acetate.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0183
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