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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Synthesis and Characterization of some heterocyclic derivatives from 2-amino thiazol and study of biological activity of prepared derivatives

Author: ZAINAB BDAIWI
Abstract: This study involves preparation of some new heterocyclic compounds, are oxazine and thiazine derivatives by several steps ,the first step is formation of azo compound by reaction between 2-amino thiazol and 5-chloro salicyladehyde.the second step is formation of chalcons derivatives via reaction between azo compound and (acetophenone,4-hydroxy acetophenone and 4-amino acetophenone) as intermediate compounds ,the third step is formation of 1,3 oxazine, 1,3 thiazine by reaction of chalcons with urea and thiourea , The prepared compounds have been characterization by melting points and some physical properties with the FTIR,H1NMR ,C13NMR spectra. All prepared compounds are examined their antimicrobial activities against two types bacteria: Gram negative (Escherichia coli) and Gram positive (Stapylococcus aureus), result showed good inhibition effect against of some bacteria.
Keyword: Azo, Chalcons 1,3 thiazine , 1,3 oxazine , thiazol.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0181
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