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Synthesis and Characterization of some heterocyclic derivatives from 2-amino thiazol and study of biological activity of prepared derivatives
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| Author:
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ZAINAB BDAIWI
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| Abstract:
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This study involves preparation of some new heterocyclic compounds, are oxazine and thiazine derivatives by several steps ,the first step is formation of azo compound by reaction between 2-amino thiazol and 5-chloro salicyladehyde.the second step is formation of chalcons derivatives via reaction between azo compound and (acetophenone,4-hydroxy acetophenone and 4-amino acetophenone) as intermediate compounds ,the third step is formation of 1,3 oxazine, 1,3 thiazine by reaction of chalcons with urea and thiourea , The prepared compounds have been characterization by melting points and some physical properties with the FTIR,H1NMR ,C13NMR spectra. All prepared compounds are examined their antimicrobial activities against two types bacteria: Gram negative (Escherichia coli) and Gram positive (Stapylococcus aureus), result showed good inhibition effect against of some bacteria.
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| Keyword:
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Azo, Chalcons 1,3 thiazine , 1,3 oxazine , thiazol.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0181
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| Download:
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