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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Muscle enzymes in newly diagnosed hypothyroid patients

Author: LALITHAMMA.A ,
Abstract: Background & Objective: In hypothyroidism Muscle involvement is common. 30-80% of hypothyroid patients presenting with symptoms such as weakness, fatigue, tiredness & myalgia. Objective of the study is to determine the level of creatine kinase, lactate dehydrogenase (LDH) and aspartate transaminase (SGOT) and other thyroid parameters before and after the treatment of hypothyroidism. Methods and Materials: 50 newly diagnosed hypothyroid cases were included in the study. Serum analysis (Serum T3, T4, TSH) was performed to confirm the hypothyroid state in all subjects and CK, LDH and SGOT levels were determined. The tests were conducted again after patients were followed up for 3 months. Results: The mean value of T3, T4, FT3, FT4 was found to be 1.03±1.63, 3.3±2.51, 1.79±0.71, 1.14± 0.93& 63.84±35.23 before treatment and 1.38 ± 0.27, 5.92 ± 1.32, 3.09 ± 1.17, 1.36 ± 0.29& 18.45 ± 13.27 respectively after 3 months of treatment.There was a statisticallysignificant difference in T4, FT3 and TSH between the pre and post treatment group (<0.001). Conclusions: In our study serum enzymes like CK, LDH and AST were elevated which may help to diagnose hypothyroidism earlier, at the same time it determines the severity of hypothyroidism.
Keyword: Aspartatransaminase (SGOT), Creatine kinase(CK), Lactate dehydrogenase (LDH), Hypothyroidism.
DOI: https://doi.org/10.31838/ijpr/2020.12.03.026
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