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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Down-Regulation ofToll-Like Receptor 4 Expression andOxidative Pathway by Toll like Receptor4antagonist Ameliorate Acute pancreatitis In Male Rats

Author: SAHAR MAJEED, ALAA GHAZI, NAJAH R. HADI
Abstract: Background:Acute pancreatitis (AP) is severeinflammation ofthe pancreas that can be of two major types:mild AP (MAP) andseveral(SAP). Objective:To study the efficacy of Ibudilast in comparison with octreotide, in the rat model of AP.Methods:A total of 48 male rats were divided into 8groupswith each group consisting of 6 rats. Acute Pancreatitis was induced by L-arginine model which has a high reproducibility. Octreotide and Ibudilastwere administered individually and in combination at 0, 8 and 16 hours after induction. After 24 hours of treatment, each rat was weighed and blood samples were withdrawn for biochemical test for total antioxidant capacity (TAC) and for Toll-like receptor 4 (TLR4).Results: In Octreotide and Ibudilast groups there was a statistically significant increase in TAC and decrease TLR4 expression. But in combination group there was no statistically significant difference between the results obtained. Conclusion:Ibudilast and octreotide can significantly attenuate the local and systemic effect of AP. The efficacy of ibudilast and octreotide are nearly the same. Their use as the combination has no preferential effect compared with each drug used alone.
Keyword: Ibudilast, Octreotide, Acute Pancreatitis, Total antioxidant capacity, Toll-Like Receptor
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0174
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