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The Potency of a Combined Amoxicillin-Ibuprofen againstStreptococcus Pyogen Isolated from Patients with Pharyngitis: A pilot study
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| Author:
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SAHAR MAJEED, FADHAA A. GHAFIL, HIDHAB J. MOHSEN, HAIDER W. MARDAN, THIKRA ABDULLAH MAHMOOD, IMAN JABBAR KADHIM, HUSSEIN ABDULKADHIM
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| Abstract:
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Background: Pharyngitis, scarlet fever, and rheumatic fever are of the major infectious problems caused by
Streptococcus Pyogen. Emergence of antibiotic- resistant strains makes such infection, its rheumatic valvular
disease,and glomerulonephritis complications a serious clinical challenge especially in children.Aims and
objectives: The main aim of this study was to investigate the synergism between ibuprofen and amoxicillin on
multidrug resistance strain of s.pyogens.Materials and Methods:S.Pyogen colony of multidrug-resistant strain
was isolated from patients, suffering Pharyngitis. The most serious strainwas cultivated to assess the Minimum
Inhibitory Concentration ofAmoxicillin-Ibuprofen combinationas compared with each alone to evaluate the
combination index.Results and conclusions: There was a significant synergism (index ? 1) at Z score= 2.3 and
P= 0.012 and betweenAmoxicillin-Ibuprofen further confirmation of MIC folds of dilutions are to be
evaluated.Recommendations: We recommended furtheringconfirming the ant streptococcal effect of the
combined Amoxicillin-Ibuprofen on more dilutions of MIC assay in patients with S.PyogenPharyngitis.
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| Keyword:
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Multidrug resistance, S.Pyogen, ibuprofen,Amoxicillin and combination index.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0173
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| Download:
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