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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The Potency of a Combined Amoxicillin-Ibuprofen againstStreptococcus Pyogen Isolated from Patients with Pharyngitis: A pilot study

Author: SAHAR MAJEED, FADHAA A. GHAFIL, HIDHAB J. MOHSEN, HAIDER W. MARDAN, THIKRA ABDULLAH MAHMOOD, IMAN JABBAR KADHIM, HUSSEIN ABDULKADHIM
Abstract: Background: Pharyngitis, scarlet fever, and rheumatic fever are of the major infectious problems caused by Streptococcus Pyogen. Emergence of antibiotic- resistant strains makes such infection, its rheumatic valvular disease,and glomerulonephritis complications a serious clinical challenge especially in children.Aims and objectives: The main aim of this study was to investigate the synergism between ibuprofen and amoxicillin on multidrug resistance strain of s.pyogens.Materials and Methods:S.Pyogen colony of multidrug-resistant strain was isolated from patients, suffering Pharyngitis. The most serious strainwas cultivated to assess the Minimum Inhibitory Concentration ofAmoxicillin-Ibuprofen combinationas compared with each alone to evaluate the combination index.Results and conclusions: There was a significant synergism (index ? 1) at Z score= 2.3 and P= 0.012 and betweenAmoxicillin-Ibuprofen further confirmation of MIC folds of dilutions are to be evaluated.Recommendations: We recommended furtheringconfirming the ant streptococcal effect of the combined Amoxicillin-Ibuprofen on more dilutions of MIC assay in patients with S.PyogenPharyngitis.
Keyword: Multidrug resistance, S.Pyogen, ibuprofen,Amoxicillin and combination index.
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0173
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