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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Some Biochemical and Histological Changes Accompanied with the treatment by Rosiglitazone in Male Rats with Induced Type 2 Diabetes Mellitus

Author: FAKHIR ALZUBAIDY, ALAA SALAH JUMAAH, QASWAR M. ALTURAIHI, 3ISMAEL K. AJAM, ASAAD A. ALJANABI, NAJAH R. HADI
Abstract: Diabetes mellitus is a common endocrine disease. It impairs glucose homeostasis.Rosiglitazone (RSG) is an efficient hypoglycemic remedy.It enhances insulin sensitivity. There a conflict regarding safety of this drug. This work was designed to solve this conflict.Fasting blood sugar were significantly dropped down in all studied groups as compared to diabetic group.All groups showed significant decrement in serum level of insulin as compared to normal control. There was significant increment in the level of serum urea level in diabetic rats. This level was signi?cantly decrease in those diabetic rats treated with RGS in a dose of 0.1 & 0.2 mg. Histological examination of the pancreas from diabetic rat’sshowing necrosis of both exocrine and endocrine pasts with lymphocytic infiltrations and vascular congestion,this in comparison with essentially normal histolologic appearance of the pancreas in all other groups. The study highlights the effectiveness of RGS in controlling blood sugar as well its protective effect on pancreas.
Keyword: RSG
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0171
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0.12
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