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The effects of the antibody directed nanosphere carrier for the combined carmustine-busulfan in human lung cancer tissue culture
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| Author:
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ZENA SAHIB, HUSSEIN ABDULKADHIM, SARMAD NORY GANY AL-DUJAILI, HAMID N. OBIED, NAJAH R. HADI
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| Abstract:
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Cancer of the lung is from the highest cancer type’s incidence. It represents a high therapeutic challenge.
Considerable adverse effects and cytotoxicity of highly potent drugs for healthy tissue require the development of
novel drug delivery systems to improve pharmacokinetics and result in selective distribution of the loaded agent.
Targeted therapy is a novel maneuver to achieve proper selectivity index. And as the main goal of nanocarriers is
to target specific sites and improve the circulation time of the drug which is entrapped, encapsulate or conjugate in
the carrier system so we chose nanoliposome as a drug carrier. Liposomes improved a potent drug targeting
successfully in the last decade, but nanoliposomes offer more surface area and they have more solubility, improve
controlled release, enhance bioavailability, and permit precision targeting of the material that is encapsulated to a
greater extent. The study aims and objectivesis formulation of HER2 Ab directed nanosphere carrier for a
combined Carmustine-busulfan and trastuzumab (LCBT), then Assessing antineoplastic efficacy of (LCBT) in lung
carcinoma cell line. From the above results, we conclude that the LCBT has a prominent anticancer effect in lung
A549 cancer cell line as it significantly decreased the growth percentage and show apoptotic effects.
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| Keyword:
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carmustine, busulfan, trastuzumab, nanoliposomes, lung A549 cell line, cytotoxicity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.0165
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| Download:
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