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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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The effects of the antibody directed nanosphere carrier for the combined carmustine-busulfan in human lung cancer tissue culture

Author: ZENA SAHIB, HUSSEIN ABDULKADHIM, SARMAD NORY GANY AL-DUJAILI, HAMID N. OBIED, NAJAH R. HADI
Abstract: Cancer of the lung is from the highest cancer type’s incidence. It represents a high therapeutic challenge. Considerable adverse effects and cytotoxicity of highly potent drugs for healthy tissue require the development of novel drug delivery systems to improve pharmacokinetics and result in selective distribution of the loaded agent. Targeted therapy is a novel maneuver to achieve proper selectivity index. And as the main goal of nanocarriers is to target specific sites and improve the circulation time of the drug which is entrapped, encapsulate or conjugate in the carrier system so we chose nanoliposome as a drug carrier. Liposomes improved a potent drug targeting successfully in the last decade, but nanoliposomes offer more surface area and they have more solubility, improve controlled release, enhance bioavailability, and permit precision targeting of the material that is encapsulated to a greater extent. The study aims and objectivesis formulation of HER2 Ab directed nanosphere carrier for a combined Carmustine-busulfan and trastuzumab (LCBT), then Assessing antineoplastic efficacy of (LCBT) in lung carcinoma cell line. From the above results, we conclude that the LCBT has a prominent anticancer effect in lung A549 cancer cell line as it significantly decreased the growth percentage and show apoptotic effects.
Keyword: carmustine, busulfan, trastuzumab, nanoliposomes, lung A549 cell line, cytotoxicity
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0165
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