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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of Obesity,FSH, LH, Prolactin and Testosterone hormones levelsoninfertile patients

Author: MAMDOOH AL-NASRAWI, DR. SAMID A. RAMADAN , ZAHRAA N. ABBAS
Abstract: Many families are suffering from infertility that requires shedding light on the role of many factors participating in this condition. Seminal fluid analysis results in the minimum overlap range with high sensitivity (78%) and specificity (92%). The area under curve showed higher motility (90%) and concentration (84%) in comparison with the morphology (70%) for WHO. Determination of hormone levels among the studied groups sera showed that LH level was highly significantly elevated (34.699± 12.947) Pg/ mlin the patient's sera in comparison with the control group (14.859± 10.487) Pg/ ml (P= 0.001).The LH level of =28. 5 IU/ml was highly significant and may be used for the differentiation between infertile and healthy fertile males with a sensitivity of 92.5%, specificity of 80.8% and accuracy of 90.1% (P=0.001). The level of LH may play a crucial role in obesity of patients whereas it has impact on semen quality and subsequently male infertility.AG to A transition was identified innt 4580 atND2 region. SNP is a synonymous substitution happening in the 3 methionine codon position, leading to the change of the ATG codon to ATA codon.
Keyword: Obesity, FSH, LH, Prolactin, Testosterone, hormones, infertilepatients
DOI: https://doi.org/10.31838/ijpr/2020.12.02.0164
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