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QUALITY ASSURANCE OF DRUG THROUGH CHEMOMETRIC EVOLUTION BY RAMAN SPECTROSCOPY
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| Author:
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DHRUTI PATEL, RANA BHUMIKA, NILESH PATEL, DHAVALKUMAR PATEL, CHETAN BORKHATARIA
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| Abstract:
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Chemometric is part of science. It is used for the extraction of data linked to physiochemical phenomena by the use of statistical and mathematical methods. Raman scattering technique is vibrational molecular spectroscopy, which originates from the inelastic light scattering process. It is a rapid, non-destructive, non-offensive method which does not need sample preparation and estimation can be done in aqueous backgrounds. It can be used for qualitative along with quantitative analysis with the help of chemometrics. Modern pharmaceutical applications cover a broad range from finding to built-up quality of drugs in the pharmaceutical industry like detecting polymorphs, monitoring concurrent methods, finding of counterfeit, and adulterated pharmaceutical products. The paper aims to review the use of Raman Spectroscopy by using Principle Component Analysis (P.C.A.), Partial Least Square (P.L.S.), and Principal Component Regression (PCR) with particular emphasis on pharmaceuticals and Dosage forms.
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| Keyword:
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chemometrics, Raman spectroscopy, P.C.A., P.L.S., PAT, pharmaceutical applications
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.230
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| Download:
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