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Preparation and Characterization of Nanocrystals for Solubility and Dissolution Rate Enhancement of Aceclofenac
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| Author:
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SHAH DHIREN P, PATEL SACHI
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| Abstract:
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Aceclofenac belongs to BCS class II anti-inflammatory drug, having poor solubility. The present research work shows preparation of Acelofenac nanocrystal containing biodegradable polymer xanthan gum, chitosan and semisynthetic polymer HPMC as stabilizers. The preliminary studies of FTIR and DSC were performed. For the optimization of stabilizer, stirring speed and stirring time, Aceclofenac nanocrystals were prepared using 0.1 % aqueous solution of xanthan gum, chitosan and HPMC at 1000 rpm and 6000 rpm for 1 hr and 6 hr. It was concluded that the formulations F4, F5 and F6 i.e., preparation of nanocrystals at 6000 rpm for 6 hr shows best result in particle size as compare to formulations F1, F2 and F3. Thus, optimized stirring speed was 6000 rpm and speed time was 6 hr. The result of particle size, polydispersity index, zeta potential and saturation solubility it was found that formulation F4 shows best result as compare to F5 and F6. Thus xanthan gum was found to be best stabilizer for the formulation of Aceclofenac nanocrystals. For the optimization of xanthan gum concentration, Aceclofenac nanocrystals were prepared using 0.05, 0.1, 0.15, 0.2 and 0.25% aqueous solution of xanthan gum. From the result of particle size, polydispersity index, zeta potential and saturation solubility it was found that the formulation F4 shows best result as compare to F1, F2, F3 and F5. Thus, 0.2% xanthan gum concentration was found to be best for the formulation of Aceclofenac nanocrystals. Results of SEM study shows that Aceclofenac nanocrytsals have crystal morphology and XRD confirms the change in the crystallinity compare to pure Aceclofenac. In vitro drug release study of Aceclofenac pure drug and optimized batch Aceclofenac nanocrystal F4 was performed. It was found that Aceclofenac nanocrystals shows rapid and higher drug release as compare to Aceclofenac pure drug. The tablets were prepared from the optimized formulation F4. Evaluation for pre-compression parameters showed that the blend has good flowing property and post- compression parameters showed good result in friability, weight variation, disintegration time and in vitro drug release. Results of stability study showed prepared formulation have good stability under accelerated conditions.
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| Keyword:
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Aceclofenac, Nanoparticles, Dissolution rate
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| EOI:
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| DOI:
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