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DESIGN, DEVELOPMENT AND CHARACTERIZATION OF ORAL MEDICATED JELLY OF ALBENDAZOLE
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| Author:
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SHAH DHIREN P, RAJA MANALI
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| Abstract:
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Albendazole is an Anthelmintic agent which is used in management of helminthiasis. The present research work was aimed to prepare oral medicated jelly of Albendazole with the purpose of provide elegant and stable oral medicated jelly which gives rapid release, quick on set of action and absorption of drug for patients having swallowing difficulties, which leads to improvement in patient’s compliance. The pre-formulation studies were carried out to check interaction between drug and gelling agent. For selection of gelling agent preliminary screening of gelling agent was carried out. Oral medicated jelly of Albendazole was prepared by using gelatin, gellan gum and pectin as gelling agent, water and sugar syrup as bulking agent, sodium Benzoate as preservative, propylene glycol as stabilizer and citric acid pH adjustment and saliva stimulating agent. The formulation was prepared and evaluated for physicochemical parameter, content uniformity, in- vitro drug release. The optimized formulation was kept for stability studies. The pre-formulation studies showed no interaction between drug and gelling agent. From the results of various physicochemical parameter, content uniformity, in vitro drug release, it was concluded that formulation P3 batch containing Pectin as gelling agent shows better release of drug as compare to other polymers. It the present study, oral medicated jelly of Albendazole was successfully formulated using gelatin, gellan gum and pectin as gelling agent. The optimized formulations showed acceptable physicochemical properties and stability. Formulation G3, Ga1 and P3 could be effectively employed for oral delivery of poorly soluble Albendazole for pediatric, geriatric and dysphasic patients as alternative to other oral dosage forms.
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| Keyword:
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Albendazole, Medicated Oral Jelly, Pectin
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| EOI:
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| DOI:
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