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Design and Evaluation of Solid Self-Microemusifying Drug Delivery System of Rosuvastatin Calcium for Dissolution Enhancement
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| Author:
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BHVYA SHAH, HITESH DALVADI, TULARAM BAROT, URMILA VACHHANI, NIRMAL VASHI
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| Abstract:
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The objective of the work was to develop a solid self-micro-emulsifying drug delivery system (S-SMEDDS) of the poorly soluble drug Rosuvastatin Calcium to increase the dissolution rate and oral bioavailability. The solubility of Rosuvastatin Calcium was determined in different vehicles. Pseudoternary phase diagrams were constructed to evaluate the micro-emulsification existence area. The liquid SMEDDS formulations were composed of Capmul MCM C8 EP, Tween 80 and polyethylene glycol 400. The liquid SMEDDS were characterized by macroscopic evaluation, droplet size, zeta-potential, cloud point, %Transmission, emulsification time and in vitro drug release. The liquid SMEDDS was converted into S-SMEDDS by using Aerosil 200 as an adsorbent in the ratio of 3:1. The S-SMEDDS was characterized by SEM, DSC, XRD and in vitro release. From the characterization of S-SMEDDS, it was revealed that liquid SMEDDS was adsorbed on the surface of Aerosil 200 and drug was present in molecularly dissolved state. In vitro release study of Rosuvastatin Calcium from S-SMEDDS showed greater extent and faster rate of drug release as compared to pure and marketed Rosuvastatin Calcium. Studies suggest that SSMEDDS can be used for faster drug release as compared to conventional tablet to improve dissolution.
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| Keyword:
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Dissolution rate, self-micro-emulsifying drug delivery system (SMEDDS), Pseudo ternary phase diagram, Zeta Potential and Capmul MCM C8 EP.
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| DOI:
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