*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
No Data found.
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Design and Evaluation of Solid Self-Microemusifying Drug Delivery System of Rosuvastatin Calcium for Dissolution Enhancement

Author: BHVYA SHAH, HITESH DALVADI, TULARAM BAROT, URMILA VACHHANI, NIRMAL VASHI
Abstract: The objective of the work was to develop a solid self-micro-emulsifying drug delivery system (S-SMEDDS) of the poorly soluble drug Rosuvastatin Calcium to increase the dissolution rate and oral bioavailability. The solubility of Rosuvastatin Calcium was determined in different vehicles. Pseudoternary phase diagrams were constructed to evaluate the micro-emulsification existence area. The liquid SMEDDS formulations were composed of Capmul MCM C8 EP, Tween 80 and polyethylene glycol 400. The liquid SMEDDS were characterized by macroscopic evaluation, droplet size, zeta-potential, cloud point, %Transmission, emulsification time and in vitro drug release. The liquid SMEDDS was converted into S-SMEDDS by using Aerosil 200 as an adsorbent in the ratio of 3:1. The S-SMEDDS was characterized by SEM, DSC, XRD and in vitro release. From the characterization of S-SMEDDS, it was revealed that liquid SMEDDS was adsorbed on the surface of Aerosil 200 and drug was present in molecularly dissolved state. In vitro release study of Rosuvastatin Calcium from S-SMEDDS showed greater extent and faster rate of drug release as compared to pure and marketed Rosuvastatin Calcium. Studies suggest that SSMEDDS can be used for faster drug release as compared to conventional tablet to improve dissolution.
Keyword: Dissolution rate, self-micro-emulsifying drug delivery system (SMEDDS), Pseudo ternary phase diagram, Zeta Potential and Capmul MCM C8 EP.
Download: Request For Article
 
Clients

Clients

Clients

Clients

Clients
ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free